Excitotoxic mitochondrial depolarisation requires both calcium and nitric oxide in rat hippocampal neurons
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منابع مشابه
Nitric oxide within the rat hippocampal CA1 area may play a role in morphine tolerance
Hippocampus as part of the limbic system plays an important role in abused drugs-induced memory. The role of glutamate receptor within the hippocampal CA1 area in morphine-induced memory has also been postulated. Previous studies indicated that glutamate receptors exert their effects in part through the release of nitric oxide (NO). In the present study, the effects of intra-CA1 area injections...
متن کاملNitric oxide within the rat hippocampal CA1 area may play a role in morphine tolerance
Hippocampus as part of the limbic system plays an important role in abused drugs-induced memory. The role of glutamate receptor within the hippocampal CA1 area in morphine-induced memory has also been postulated. Previous studies indicated that glutamate receptors exert their effects in part through the release of nitric oxide (NO). In the present study, the effects of intra-CA1 area injections...
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Production of nitric oxide (NO) by glial cells has been proposed to mediate cytotoxic effects on neighboring neurons. Although extensive genetic data implicate the beta amyloid peptide (Abeta) in the neurodegenerative cascade of Alzheimer's disease (AD), the molecular mechanisms underlying its effects on neurons and glia and the relationship between glial activation and neuronal death are not w...
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Mitochondrial membrane potential (DeltaPsim)-dependent Ca2+ uptake plays a central role in neurodegeneration after NMDA receptor activation. NMDA-induced DeltaPsim dissipation increases during postnatal development, coincident with increasing vulnerability to NMDA. NMDA receptor activation also produces nitric oxide (NO), which can inhibit mitochondrial respiration, dissipating DeltaPsim. Becau...
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Abstract: Introduction: Nitric oxide (NO) is a retrograde messenger in hippocampal synaptic plasticity which involves in learning and memory processes. Previous studies revealed that hippocampal pyramidal cells contain NO synthase (NOS) enzyme which produce NO and could be a promising target to evaluate the role of NO in brain cognitive functions. So in this study, using NOS inhibitor (L-NAME)...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1999
ISSN: 0022-3751
DOI: 10.1111/j.1469-7793.1999.00797.x